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Results The results show that in each country, achieving national coverage targets for just four or five high-impact interventions could reduce under-5 mortality by at least 20% by 2011, relative to 2006 levels.

The CI aims to accelerate coverage of interventions proven to be efficacious in reducing mortality from major causes of mortality in children under the age of 5 years, resulting in rapid reductions in child mortality at scale.Here, we also present the total and intervention-specific reductions in under-5 mortality that would result from achieving 80% coverage with the highest-impact interventions in each country to illustrate the maximum impact that could be achieved by accelerating coverage for the most effective interventions focused on the major causes of child death in each country.Table 3 presents the number of interventions included in the country scale-up plan, the number of interventions modelled and the overall level of child mortality reduction between 20 if national coverage targets are achieved.The Institute for International Programs (IIP) at the Johns Hopkins University is responsible for conducting independent effectiveness evaluations of CI activities at country level in collaboration with in-country research partners.These evaluations are prospective, require innovative evaluation designs and are guided by principles that differ from most traditional evaluations: (i) the evaluations are based on a stepwise approach that includes early assessments of the programme design and the likelihood of achieving impact; (ii) use of to provide detailed input to programme planners allowing them to make changes to initial plans and increase the probability of impact; (iii) independence from programme implementers with responsibility for providing regular feedback to improve programme effectiveness; and (iv) designs that are flexible and realistic, recognizing that good programmes change over the course of their implementation in response to contextual factors and ongoing feedback from internal and external monitoring and evaluation.

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